The ancient Silk Road functioned as a pivotal network facilitating cultural, biological, and material exchange across Eurasia. Mid-latitude Asia, situated at the heart of the Silk Road, encompasses cold, arid, and high-altitude oxygen-deficient zones. Characterized by fragile and sensitive ecosystems, this region provides an ideal setting for studying past human-environment relationship. With a long history of human activity, cultural elements from Eastern and Western Eurasia converged in mid-latitude Asia during the Mid-to-Late Holocene, forging unique economic, cultural, and social systems. Throughout this process, the dynamics of human-environment interactions and exchange remain inadequately understood. Study on these harsh regions require cross-regional and interdisciplinary approaches, therefore, we invite papers exploring past cultural exchanges and human-environment interactions in arid, dry and hypoxia regions of Asia.